Luer to luer tissue morselizer

ABSTRACT

A morselizer comprising (a) a hollow cylindrical structure with an inner wall and an outer wall and comprising a first end section, a second end section, and a center section extending axially between the first end section and the second end section providing a substantially axial liquid pathway therein; (b) wherein each end section comprises a axially and radially hollow luer fitting that is attachable to a structure with a complementarily sized luer fitting; and (c) one or more blades extending transversally across the inner diameter of the center section wherein (i) each blade is comprised of a plurality of ends, including a posterior end secured to at least the center wall section inner wall at a center section inner wall first position and an anterior end proximal a center section inner wall second position opposite the center section inner wall first position, with a gap positioned between the blade anterior end and the center section inner wall second position, and (ii) at least two ends comprise cutting ends.

CLAIM OF PRIORITY

This application claims the benefit of U.S. Provisional Application62/589,782 filed Nov. 22, 2017.

FIELD OF THE INVENTION

The present invention relates to an apparatus with luer or similarfitting for use in atraumatically resizing biologic material.

BACKGROUND OF THE INVENTION

The attachment of a first structure with a male tapered fitting to asecond structure with a conforming taper providing a female taperedfitting that is mateable to the first structure male tapered fitting,with a portion of the male tapered fitting of the first structureaccommodated within a portion of the female tapered fitting of thesecond structure, such as the one described in U.S. Pat. No. 5,312,377to Dalton, is widely used in the medical field to connect two liquidconduits end to end. These so-called luer fittings provide anISO-standardized system (ISO 80369, “Small-Bore Morselizer Standards”,referencing ISO 594-1 and ISO 594-2 therein) across small-scale liquidfittings in order to make leak-free connections between two structures,such as a male luer fitting of a structure mateably attachable to afemale luer fitting of another structure. These luer fittings are (i)common across medical and laboratory instruments to makeleak-free/leakproof, mechanically secure connections between two parts,such as to join hypodermic needles to syringes or one catheter toanother catheter; and (ii) described as having a male luer fitting andits mating female luer fitting, with the male luer fitting inserted intothe female luer fitting and accommodated therein.

Often, such luer fittings are threaded to allow for a threadedattachment between structures with mateable luer fittings, which iscommonly referred to as a “luer lock.” Such luer lock fittings aredivided into two types called one piece luer lock and two piece luerlock or rotating collar luer lock. The one piece luer lock fitting comesas a single mold, with attachment of a structure with such a fitting toanother structure with a conforming luer fitting achieved by rotatingthe entire fitting. In two piece or rotating collar luer lock, a freerotating threaded collar is assembled to the luer fitting and theattachment of a structure with such a fitting to another structure witha conforming luer fitting is achieved by rotating the collar.Alternatively, a structure with a luer fitting that is non-threaded canattach to another structure with a conforming luer taper dimension asthat of the first structure, with the luer fittings of the conformingstructures pressed together, with frictional forces holding thestructures together. This is commonly referred to as luer slip or sliptip. The locking luer lock style luer fittings are generally more secureas one structure with an insertive luer (male) fitting is (i) insertedinto another structure with a receptive luer (female) fitting and (ii)twisted to form a luer lock attachment, thus preventing accidentalseparation of the structures in addition to ensuring no liquids can leakthrough the attachment. Although not having a threaded attachmentaugmenting the frictional forces between the two attached structures,the luer slip style fitting allows for quicker attachment between twostructures with complementarily sized luer fittings as the attachmentsimply requires a push of the structures together to form the attachmentthrough the frictional forces between the structures.

In the cosmetic and plastic surgery field, fat injections, also known asfat grafting, are performed. Such procedures can be an effective way toreduce wrinkles, diminish acne scarring, and regain a more youthfulappearance. By injecting harvested human fat, cosmetic and plasticsurgeons can enhance facial fullness, fill deep creases, soften facialcreases and wrinkles, plump up lips, and build up shallow contours. Inorder to be effective, fat particles injected into the face should be nolarger than 1 mm in diameter.

The harvesting of fat with a cannula (a thin tube inserted into the fattissue) is performed as a means of providing fat particles forinjection. A common procedure for harvesting fat, also referred to as“lipoharvest,” is called the “Coleman technique” and involves a 2 to 3mm diameter blunt cannula with a luer fitting attached to a 10-mLsyringe with a luer fitting.

When injecting fat into a desired area, the diameter of the injectionneedle should be similar or slightly larger than the cannula opening(s)in order to avoid damage to the fat particles. In addition, to avoid anyunnecessary skin damage when performing fat injection, it is desirableto be able to inject the harvested fat with very narrow-diameterneedles, viz., 0.5 to 2.5 mm, to make only small diameter wounds in theskin. However, in order to harvest smaller particles that can passthrough such needles, cannulas have been manufactured with smaller holesthan traditional cannulas. Although smaller fat particles are obtained,the beneficial fraction comprised of the desirable stromal vascularfraction (SVF) containing a large population of regenerative cellscalled adipose derived regenerative cells (ADRCs) comprised in part offibroblasts and stem cells.

As such, it is desirable to harvest larger particles containing the SVFand have a device that allows for atraumatic resizing of the relativelylarge harvested fat particles without loss of the beneficial SVfraction, while not losing sight of the need for smaller particles toensure survival until the new blood supply is established to allow forthe injection of effectively-sized fat particles (viz., no larger than 1mm).

SUMMARY OF THE INVENTION

A first aspect of the invention comprises a morselizer comprising (a) ahollow cylindrical structure with an inner wall and an outer wall andcomprising a first end section, a second end section, and a centersection extending axially between the first end section and the secondend section providing an axial liquid pathway therein; (b) wherein eachend section comprises an axially and radially hollow luer fitting thatis attachable to a structure with a complementarily sized luer fitting;and (c) one or more blades extending transversally across the innerdiameter of the center section wherein (i) each blade is comprised of aplurality of ends, including a posterior end secured to at least thecenter wall section inner wall at a center section inner wall firstposition and an anterior end proximal a center section inner wall secondposition opposite the center section inner wall first position, with agap positioned between the blade anterior end and the center sectioninner wall second position, and (ii) at least two ends comprise cuttingends.

A second aspect of the invention comprises a morselizer comprising (a) ahollow cylindrical stricture with an inner wall and an outer wall andcomprising a first end section, a second end section, and a centersection extending axially between the first end section and the secondend section providing an axial liquid pathway therein; (b) wherein eachend section comprises an axially and radially hollow luer fitting thatis attachable to a structure with a complementarily sized luer fitting;(c) wherein the first end section comprises a threaded male luer fittingwith a plurality of threads formed on the first end section outer wall;and (d) one or more blades extending transversally across the innerdiameter of the center section wherein (i) each blade is comprised of aplurality of ends, including a posterior end secured to at least thecenter wall section inner wall at a center section inner wall firstposition and an anterior end proximal a center section inner wall secondposition opposite the center section inner wall first position, with agap positioned between the blade anterior end and the center sectioninner wall second position, and (ii) at least two ends comprise cuttingends.

A third aspect of the invention comprises a morselizer comprising (a) ahollow cylindrical structure with an inner wall and an outer wall andcomprising a first end section, a second end section, and a centersection extending axially between the first end section and the secondend section providing an axial liquid pathway therein; (b) wherein eachend section comprises an axially and radially hollow luer fitting thatis attachable to a structure with a complementarily sized luer fitting;(c) wherein the first end section comprises a threaded female luerfitting with a plurality of threads formed on the first end sectioninner wall; and (d) one or more blades extending transversally acrossthe inner diameter of the center section wherein (i) each blade iscomprised of a plurality of ends, including a posterior end secured toat least the center wall section inner wall at a center section innerwall first position and an anterior end proximal a center section innerwall second position opposite the center section inner wall firstposition, with a gap positioned between the blade anterior end and thecenter section inner wall second position, and (ii) at least two endcomprise cutting ends.

A fourth aspect of the invention comprises a morselizer comprising (a) ahollow cylindrical stricture with an inner wall and an outer wall andcomprising a first end section, a second end section, and a centersection extending axially between the first end section and the secondend section providing an axial liquid pathway therein; (b) wherein eachend section comprises an axially and radially hollow luer fitting thatis attachable to a structure with a complementarily sized luer fitting;(c) wherein the first end section comprises a threaded female-male luerfitting with a plurality of threads formed on the first end sectioninner wall and the first end section outer wall; and (d) one or moreblades extending transversally across the inner diameter of the centersection wherein (i) each blade is comprised of a plurality of ends,including a posterior end secured to at least the center wall sectioninner wall at a center section inner wall first position and an anteriorend proximal a center section inner wall second position opposite thecenter section inner wall first position, with a gap positioned betweenthe blade anterior end and the center section inner wall secondposition, and (ii) at least two ends comprise cutting ends.

The morselizer allows for atraumatic resizing of material through themorselizer by (I) attaching a first structure with a luer fittingcontaining fat tissue with its collagen supporting structure (SVF) in asubstantially liquid solution to the morselizer by attaching the firststructure luer fitting to the luer fitting at the first end section ofthe morselizer and attaching a second structure with a luer fitting tothe luer fitting at the second end of the morselizer; and (II)transferring the solution from the first structure to the morselizerthrough the first structure-morselizer luer fitting attachment, thencethrough the morselizer center section where material is resized by theone or more blades positioned in the morselizer center section andthrough the second end section of the morselizer to the second structurethrough the second structure-morselizer luer fitting attachment; and, asneeded or desired by the user, (III) successively transferring solutionfrom the second structure through the morselizer to the first structureand thence back to the second structure through the morselizer asdiscussed above at (II).

Although the invention described herein is done so in the context of fatharvesting for injection into the body, the invention is useable in anymedical or other scientific procedure wherein substantially solidmaterial, such as particles of a larger size, are atraumatically resizedto a smaller desired size.

Further additional, advantageous aspects of the invention, such asvariants of the aspects of the invention disclosed above, will becomeapparent to one of ordinary skill in the art upon review of thefollowing description of the embodiments of the invention and the claimsand with reference to the accompanying drawings.

By way of example only, specific embodiments of the invention will nowbe described, with reference to the accompanying drawings, in which:

DESCRIPTION OF THE DRAWINGS

FIG. 1 is a side elevation view of an embodiment of the presentinvention;

FIG. 2 is a side elevation view of an embodiment of the presentinvention spaced apart from a plurality of structures, each with a luerfitting;

FIG. 3 is a side elevation view of an embodiment of the presentinvention attached to a plurality of structures, each with a luerfitting;

FIG. 4 is a side elevation view of an embodiment of the presentinvention spaced apart from a plurality of structures, each with a luerfitting;

FIG. 5 is side elevation view of an embodiment of the present inventionattached to a plurality of structures, each with a luer fitting;

FIG. 6 is a side elevation view of an embodiment of the presentinvention spaced apart from a plurality of structures, each with a luerfitting;

FIG. 7 is side elevation view of an embodiment of the present inventionattached to a plurality of structures, each with a luer fitting;

FIG. 8 is a partial side elevation view of an embodiment of the presentinvention spaced apart from a structure with a leer fitting; and

FIG. 9 is a cross-sectional end view of an embodiment of the presentinvention.

DETAILED DESCRIPTION OF THE INVENTION

Referring to FIGS. 1-9, morselizer 10 comprises a hollow structure,preferably a thin-walled cylinder, with an inner wall I and an outerwall O and extending axially from a first end and a second end (i.e.,the cylinder flat surfaces or bases), wherein both ends are open.Morselizer 10 can be made of any one or more materials known in the art,such as glass, preferably laboratory-grade glass; metal; or plastic,preferably a plastic impervious to and non-degraded by aqueous andorganic solutions.

With reference to FIGS. 1-7, morselizer 10 is comprised of first endsection 12, second end section 14, and center section 16 extendingaxially between first end section 12 and second end section 14. The axisof morselizer 10 provides an axial liquid pathway along the hollowstructure thereof, extending from first end section 12 to center section16 and then to second end section 14. Preferably, the inner diameter ofmorselizer 10 is axially continuous, with the inner diameters of each offirst end section 12, second end section 14, and center section 16 thesame. Morselizer 10 can have an inner diameter of any size capable ofbeing complementarily sized to structures with small-scale liquidfittings, preferably in the range of 0.1 mm to 10 mm, more preferably inthe range of 2 to 5 mm, most preferably in the range of 3 to 4 mm, withan outward bevel extending from center section 16 to first end section12 and second end section 14.

With reference to FIGS. 1-7, each end section 12/14 of morselizer 10comprises an axially and radially hollow luer fitting that is attachableto a structure with a complementarily sized luer fitting. The attachmentof the morselizer 10 at the each of the end sections 12 and 14comprising a luer fitting to a structure containing a substantiallyliquid solution with substantially solid materials suspended therein andhaving a complementarily sized luer fitting prevents any solutionleakage out of the structure during material flow from the structure tomorselizer 10. The structure with a complementarily sized luer fittingand attachable to the morselizer 10 at each of the end sections 12/14can comprise any structure with a luer fitting or luer-compatiblefitting (such as a non-luer fitting to luer fitting adapter or otherluer to non-luer adaptive structure), such as laboratory glassware,plasticware, or metalware, including, by way of example only and not oflimitation, vials, tubes (boiling, test, Thiele), luer lock tip or luerslip tip syringes, burettes, pipettes, cylinders, flasks, beakers,funnels, distilling columns, chromatography columns or other columnsused in analytical techniques, or condensers.

The luer fittings comprising end sections 12/14 can be characterized aseither (i) “male”, with the luer fitting on end section 12/14 ofmorselizer 10 accommodated within another structure with a luer fittingwhen the structure is attached to the morselizer 10; or (ii) “female”,with the luer fitting on end section 12/14 of morselizer 10accommodating therein another structure with a luer fitting when thestructure is attached to the morselizer 10. Moreover, morselizer endsection 12/14 comprising a luer fitting can be threaded or unthreaded,with such threaded or unthreaded morselizer end section 12/14 attachableto a complementarily sized unthreaded or threaded luer fitting on astructure, with (i) the threaded mating and frictional forces generatedbetween the structure and morselizer 10 maintaining the attachment of athreaded morselizer end section 12/14 to a threaded structure and (ii)frictional forces alone maintaining the morselizer-structure attachmentin the absence of a mating of threads between the morselizer end section12/14 and the structure fitting.

With reference to FIGS. 1-7, in an embodiment of the invention, formedon an inner wall (female) (FIGS. 2-3), outer wall (male) (FIGS. 1, 4-7),or both outer and inner walls (male-female, not depicted) of morselizerend section 12/14 comprising a luer fitting are a plurality of threadsto allow for a threaded attachment of the end section 12/14 ofmorselizer 10 to a structure with a complementarily sized threaded orunthreaded luer fitting. In an embodiment of the invention, a threadedluer fitting of end section 12/14 of morselizer 10 is attachable to astructure with a complementarily sized unthreaded luer fitting such asthe fitting. In another embodiment of the invention and with referenceto FIG. 8, one or more of end sections 12/14 (shown as end section 12 inFIG. 8) comprises an threaded luer fitting that is attachable to astructure 20 with a complementarily sized unthreaded luer fitting 28 bypressing the morselizer 1 and structure 20 together so as to form a luerslip attachment between the morselizer end section and the structureluer fitting, with the attachment of a morselizer end section 12/14comprising a threaded luer fitting to a complementarily sized unthreadedluer fitting on a structure effectuated from frictional forces generatedbetween the structure and morselizer 10.

In an embodiment of the invention and with reference to FIGS. 1-3, oneor more of end sections 12 and 14 of morselizer 10 comprises a femaleluer fitting wherein the inner wall of such end sections 12/14 hasdisposed thereon a plurality of threads so as to threadedly attach suchmorselizer end section 12/14 to a structure (30 or 40 as shown in FIGS.2-3) with a complementarily sized male luer fitting with a plurality ofthreads formed on the outer wall of such structure (32 or 42, as shownin FIGS. 2-3), such plurality of threads mateable to the plurality ofthreads of morselizer end section 12/14, with the female luer fittingend section 12/14 securely accommodating therein the male luer fitting(32 or 42 as shown in FIGS. 2-3) of the mateable structure (30 or 40 asshown in FIGS. 2-3).

In an embodiment of the invention, each end section 12 and 14 ofmorselizer 1 comprises a threaded female luer fitting and can beattached to a structure with a complementarily sized threaded male luerfitting. With reference to FIGS. 2-3, each of first end section 12 andsecond end section 14 of morselizer 10 comprises an axially and radiallyhollow female luer fitting with an inner wall having a plurality ofthreads disposed thereon so as to allow for a threaded attachment of (i)morselizer 10 at first end section 12 to a first structure 30 at thefirst structure threaded luer fitting 32, with the first structurethreaded luer fitting 32 accommodated within the morselizer first endsection 12, and (ii) morselizer 10 at second end section 14 to a secondstructure 40 at the second structure threaded luer fitting 42, with thesecond structure threaded luer fitting 42 accommodated within themorselizer second end section 14.

In another embodiment of the invention, a female threaded luer fittingend section 12/14 as that described above is attachable to a structurewith an unthreaded complementarily sized male luer fitting (such as Luerfitting 28 on structure 20 in FIG. 8) by pressing the morselizer 1 andthe attachable structure together (not depicted) forming a Luer slipattachment between the morselizer and the structure.

In another embodiment of the invention, formed on the outer wall of afemale threaded luer fitting end section 12/14 is a plurality of threadsso as to render end section 12/14 a male-female luer fitting which couldalternatively threadedly accommodate in the interior of end section12/14 a male threaded luer fitting of a structure or be threadedlyaccommodated within a female threaded luer fitting of a stricture (notdepicted).

In an embodiment of the invention and with reference to FIGS. 4-7, oneor more of end sections 12 and 14 of morselizer 10 comprises a male luerfitting wherein the outer wall of such end sections 12/14 has disposedthereon a plurality of threads so as to threadedly attach suchmorselizer end section 12/14 to a structure, such as structure 52/54 asshown in FIGS. 4-7, with a complementarily sized female luer fittingwith a plurality of threads formed on the inner wall of such structure52/54 as shown in FIGS. 4-7, such plurality of threads mateable to theplurality of threads of morselizer end section 12/14, with the femaleluer fitting of the structure 52/54 securely accommodating therein themale luer fitting of morselizer end section 12/14 as shown in FIGS. 4-7.

In an embodiment of the invention, each end section 12 and 14 ofmorselizer 1 comprises a threaded male luer fitting and can be attachedto a structure with a complementarily sized threaded female luerfitting. With reference to FIGS. 4-7, each of first end section 12 andsecond end section 14 of morselizer 10 comprises an axially and radiallyhollow male luer fitting with an outer wall having a plurality ofthreads disposed thereon so as to allow for a threaded attachment of (i)morselizer 10 at first end section 12 to a first structure at the firststructure threaded female Luer fitting 52, with the male fitting offirst end section 12 accommodated within the first structure female luerfitting 52 and (ii) morselizer 10 at second end section 14 to a secondstructure 40 at the second structure threaded female luer fitting 42,with the male fitting of second end section 14 accommodated within thesecond structure female luer fitting 42.

In another embodiment of the invention, a male threaded luer fitting endsection 12/14 as that described above is attachable to a structure withan unthreaded complementarily sized female luer fitting by pressing themorselizer 1 and the attachable structure together (not depicted).

In another embodiment of the invention, formed on the inner wall of amale threaded luer fitting end section 12/14 is a plurality of threadsso as to render end section 12/14 a male-female luer fitting which couldalternatively threadedly accommodate a male threaded luer fitting of astructure in the interior of end section 12 or be threadedlyaccommodated within a female threaded luer fitting of a structure (notdepicted).

In some embodiments of the invention and with reference to FIG. 9, oneor more end sections 12/14 of morselizer 10 has attached to andoverlaying the outer wall O of such one or more end sections 12/14 acollar C, with the collar C having an inner wall proximal the outer wallO of morselizer end section 12/14 and having formed thereon a pluralityof threads, wherein the collar C is freely rotatable and, when rotated,partially axially displaceable from morselizer outer wall O ofmorselizer end section 12/14 to allow for a threaded attachment of thecollar C to a structure with a complementarily sized threaded luerfitting to form a two piece rotating collar luer lock attachment betweenmorselizer 10 and the structure, with the structure luer fittingaccommodated within the inner wall of the collar C.

Often, a structure has a liter fitting comprising an inner hollow core,within which is the liquid flow path, extends and protrudes from anouter hollow sleeve, with the inner core forming a tip, such as the luerfittings 52 and 54 shown in FIGS. 4 and 5, with the inner wall of thesleeve having positioned thereon a plurality of threads. Such astructure, often referred to as a threaded luer lock tip, threaded Luertip, or simply luer tip (such structure hereinafter “luer tipstructure”), is attachable to a morselizer end section 12/14 comprisinga luer fitting having a plurality of threads formed on the outer wall ofsuch end section 12/14 (male luer fitting), with such end section 12/14threadedly attached to the luer tip structure 52/54, wherein theplurality of threads of male luer fitting of end section 12/14 arecomplementarily mateable to the plurality of threads on the inner wallof the sleeve of the luer tip structure luer fitting 52/54, with the endsection 12/14 of morselizer 1 (i) accommodating therein the core of theluer tip structure luer fitting 52/54 and (ii) accommodated within thesleeve of the luer tip structure luer fitting 52/54.

In another embodiment of the invention, a morselizer end section 12/14comprising a luer fitting having a plurality of threads formed on theinner wall of such end section 12/14 is attachable to a structure 52/54with a luer tip fitting 52/54, with frictional forces between morselizer1 and the structure 52/54 maintaining the end section 12/14—structure52/54 attachment.

With reference to FIGS. 1-9, positioned in center section 16 is one ormore blades 18, preferably one blade 18. With reference to FIG. 1, eachof the one or more blades 18 is a planar structure defined by posteriorand anterior ends and at least two side ends wherein at least two ends,preferably the two side ends, comprise cutting ends, such blade 18comprising (i) a first end 182 proximal first end section 12 andpreferably comprising a cutting end, (ii) a posterior end 186 secured tomorselizer 10 at center section 16, (iii) a second end 184 proximalsecond end section 14 and preferably comprising a cutting end, and (iv)an anterior end 185 positioned in the hollow interior of morselizer 10at center section 16, preferably comprising a cutting end, morepreferably ending at a point. Such one or more blades 18 extendstransversally from the blade posterior end 186 at a center section innerwall first position across the inner diameter of center section 16 tothe blade anterior end 185 to a position short of a center section innerwall second position opposite the center section inner wall firstposition, leaving a gap G between the blade anterior end 185 and thecenter section inner wall second position.

In a preferred embodiment, posterior blade end 186 is secured tomorselizer 10 inner wall at center section 16 by a glass-to-metal seal.More preferably, posterior blade end 186 extends through morselizer 10inner wall with a glass-to-metal seal formed in the glass matrix betweenthe inner and outer walls of morselizer 10 at center section 16.Additionally and preferably, the one or more blades 18 are axiallypositioned toward the axial midpoint of morselizer 10 at center section16, preferably with at least one of the one or more blades 18 axiallypositioned at the axial midpoint of morselizer 10 at the center section16 axial midpoint.

Each of the one or more blades 18 positioned in center section 16comprises any blade type known in the art. Preferably, at least one ofthe one or more blades 18 comprises a scalpel blade, more preferably, adouble-sided scalpel blade 18 with first end 182 proximal first endsection 12 and second end 184 proximal second end section 14 whereinfirst cutting 182 and second cutting edge 184 each extend transversallyacross center section 16 and taper toward each other forming anteriorend 185 and ending at a blade point proximal the inner diameter ofcenter section 16.

The morselizer allows for atraumatic resizing of material through axialliquid transfer through the axial liquid pathway of the morselizer by(I) attaching a first structure with a Luer fitting containing materialin a liquid solution to the morselizer by attaching the first structureluer fitting to the morselizer luer fitting at the first end section ofthe morselizer and attaching a second structure with a luer fitting tothe morselizer luer fitting at the second end of the morselizer; and(II) transferring material in the liquid solution from the firststructure to the morselizer through the first structure-morselizer luerfitting attachment, thence through the morselizer center section wherematerial is resized by the one or more blades positioned in themorselizer center section and through the second end section of themorselizer to the second structure through the secondstructure-morselizer luer fitting attachment; and, as needed or desiredthe user depending on the given size of the diameter and the desiredsize of the diameter, (III) successively transferring material in theliquid solution from the second structure through the morselizer to thefirst structure and thence back to the second structure through themorselizer as discussed above at (II). The desired size of theatraumatically resized material is determined in large part by the sizeof the gap G separating the one or more blades 18 and the center section16 inner wall, with the average diameter of the desired materialapproximating the size of the gap G.

Although the description above contains much specificity, suchdescription specificity should not be construed as limiting the scope ofthe embodiments of the invention but as merely providing illustrationsof some of the presently-preferred embodiments. Thus, the scope of theinvention should be determined by the appended claims and their legalequivalents, rather than by the examples given.

I claim:
 1. A morselizer comprising: a. a hollow cylindrical structurewith an inner wall and an outer wall and comprising a first end section,a second end section, and a center section extending axially between thefirst end section and the second end section providing an axial liquidpathway therein; b. wherein each end section comprises an axially andradially hollow luer fitting that is attachable to a structure with acomplementarily sized luer fitting; c. wherein the first end sectioncomprises a threaded female-male luer fitting with a plurality ofthreads formed on the first end section inner wall and the first endsection outer wall; d. wherein the second end section comprises athreaded female-male luer fitting with a plurality of threads formed onthe second end section inner wall and the second end section outer wall;and e. one blade extending transversally across the inner diameter ofthe center section wherein (i) the blade is comprised of a plurality ofends, including a posterior end secured with a glass-to-metal sealbetween the inner wall of the center section and the outer wall of thecenter section at a midpoint of the center section and an anterior endextending straight down from the posterior end, a gap positioned betweenthe anterior end and the inner wall of the center section, the gap equalin size to a desired diameter of material to flow through themorselizer, and (ii) a pair of cutting edges, wherein a first cuttingedge is proximal the first end section and a second cutting edge isproximal the second end section, the first cutting edge and the secondcutting edge each extend transversally across the center section andtaper inward forming the anterior end.
 2. A morselizer as claimed inclaim 1, wherein the second end section comprises a threaded collaredluer fitting comprising a collar comprised of a cylindrical structurewith an inner wall and an outer wall, said collar attached to andoverlaying the second end section outer wall, wherein the collar has aplurality of threads formed on the collar inner wall and is freelyrotatable and partially axially displaceable from the second end sectionouter wall and attachable to a complementarily sized threaded luerfitting on a structure forming a rotating collar luer lock attachmentbetween the morselizer second end section and the structure luerfitting.
 3. A morselizer as claimed in claim 1, wherein the second endsection comprises a luer fitting selected from the group consisting of(i) an unthreaded luer fitting attachable to a complementarily sizedunthreaded luer fitting on a structure forming a luer slip attachmentbetween the morselizer end section and the structure luer fitting, or(ii) a male-female luer fitting with a plurality of threads formed onthe end section inner wall and a plurality of threads formed on the endsection outer wall.
 4. A morselizer as claimed in claim 1, wherein thecenter section has a diameter in a range of 2 to 5 mm.
 5. A morselizeras claimed in claim 1, wherein the center section has a diameter in arange of 3 to 4 mm.